SH2-inositol phosphatase 1 negatively influences early megakaryocyte progenitors Article (Faculty180)

cited authors

  • Perez, Lia E; Desponts, Caroline; Parquet, Nancy; Kerr, William G

description

  • The SH2-containing-5'inositol phosphatase-1 (SHIP) influences signals downstream of cytokine/chemokine receptors that play a role in megakaryocytopoiesis, including thrombopoietin, stromal-cell-derived-Factor-1/CXCL-12 and interleukin-3. We hypothesize that SHIP might control megakaryocytopoiesis through effects on proliferation of megakaryocyte progenitors (MKP) and megakaryocytes (MK).

authors

publication date

  • 2008

published in

start page

  • e3565

volume

  • 3