Bortezomib restores stroma-mediated APO2L/TRAIL apoptosis resistance in multiple myeloma Article (Faculty180)

cited authors

  • Perez, Lia E; Parquet, Nancy; Meads, Mark; Anasetti, Claudio; Dalton, William

description

  • Hematopoietic stroma promotes resistance to immune control by APO2L/TRAIL in multiple myeloma (MM) cells in part by increasing synthesis of the anti-apoptotic protein c-FLIP. Here, we tested whether bortezomib can reverse the APO2L/TRAIL environmental mediated-immune resistance (EM-IR).

authors

publication date

  • 2010

published in

start page

  • 212

end page

  • 22

volume

  • 84