Liu, Jehnan; Muturi, Harrison T; Khuder, Saja S S; Helal, R A; Ghadieh, Hilda E; Ramakrishnan, Sadeesh K; Kaw, Meena K; Lester, Sumona G; Al-Khudhair, Ahmed; Conran, Philip B; Chin, Khew- V; Gatto-Weis, Cara; Najjar, Sonia M
description
PTEN haploinsufficiency plays an important role in prostate cancer development in men. However, monoallelic deletion of Pten gene failed to induce high prostate intraepithelial neoplasia (PIN) until Pten mice aged or fed a high-calorie diet. Because CEACAM1, a cell adhesion molecule with a potential tumor suppression activity, is induced in Pten prostates, the study aimed at examining whether the rise of CEACAM1 limited neoplastic progression in Pten prostates.
