Lin, Boren; Launder, Dylan; Bailey, Destin Y; Assifuah, Fran K; Miller, Olivi A; Conti, Heathe R; Du, Jianyang; Koffman, Boyd M
description
Multiple sclerosis (MS) is an immune-mediated neurodegenerative disease in the central nerve system, in which both innate and adaptive immune cells are involved. BBR3378, an aza-anthrapyrazole prevents experimental autoimmune encephalomyelitis (EAE), an inflammatory condition similar to MS, by antagonizing T cell autoimmune responses. Here, we report BBR3378's regulatory effect on macrophages.
