Barkoudah, Ebrahim; van Thiel, Bibi S; Fisher, Naomi D; Gregg, Rich A; Danser, A H; Moukarbel, George V; Hollenberg, Norman K
description
Renin inhibition with aliskiren induced the largest increases in renal plasma flow (RPF) in salt-depleted healthy volunteers of all renin-angiotensin system (RAS) blockers. However, given its side-effects at doses higher than 300 mg, no maximum effect of renin inhibition could be established. We hypothesized that VTP-27999, a novel renin inhibitor without major side-effects at high doses, would allow us to establish this.
