Menin liver-specific hemizygous mice challenged with high fat diet show increased weight gain and markers of metabolic impairment Article (Faculty180)

cited authors

  • Wuescher, L; Angevine, K; Patel, P R; Mensah-Osman, E


  • The menin tumor suppressor protein is abundantly expressed in the liver, although no function has been identified because of lack of tumor development in multiple endocrine neoplasia type 1 (Men1) null livers. We examine the phenotype of mice lacking one functional allele of Men1 (consistent with the phenotype in humans with MEN1 syndrome) challenged with high fat diet (HFD) to elucidate a metabolic function for hepatic menin.


publication date

  • 2012

published in

start page

  • e34


  • 2