Estrogen receptor α and aromatase polymorphisms affect risk, prognosis, and therapeutic outcome in men with castration-resistant prostate cancer treated with docetaxel-based therapy
Article (Faculty180)
Sissung, Tristan M; Danesi, Romano; Kirkland, C T; Baum, Caitlin E; Ockers, Sandra B; Stein, Erica V; Venzon, David; Price, Douglas K; Figg, William D
description
Reactive estrogen species cause genotoxicity and interfere with docetaxel-mediated tubulin polymerization resulting in shortened survival in men with castrate-resistant prostate cancer (CRPC).