ABCB1 genetic variation influences the toxicity and clinical outcome of patients with androgen-independent prostate cancer treated with docetaxel
Article (Faculty180)
Sissung, Tristan M; Baum, Caitlin E; Deeken, John; Price, Douglas K; Aragon-Ching, Jeanny; Steinberg, Seth M; Dahut, William; Sparreboom, Alex; Figg, William D
description
Polymorphisms that are associated with ABCB1 expression and function may be linked to treatment efficacy and the development of neutropenia and neurotoxicity in patients with androgen-independent prostate cancer receiving docetaxel.