PD-1-dependent restoration of self-tolerance in the NOD mouse model of diabetes after transient anti-TCRβ mAb therapy Article (Faculty180)

cited authors

  • Schroder, Paul M; Khattar, Mithun; Baum, Caitlin E; Miyahara, Yoshihiro; Chen, Wenhao; Vyas, Rohit; Muralidharan, Shravan; Mierzejewska, Beata; Stepkowski, Stanislaw M


  • T cells play a major role in the pathogenesis of type 1 diabetes, and there is great interest in developing curative immunotherapies targeting these cells. In this study, a monoclonal antibody (mAb) targeting the T cell receptor β-chain (TCRβ) was investigated for its ability to prevent and reverse disease in mouse models of diabetes.


publication date

  • 2015

published in

start page

  • 1309

end page

  • 18


  • 58