Hypertension and hand-foot skin reactions related to VEGFR2 genotype and improved clinical outcome following bevacizumab and sorafenib Article (Faculty180)

cited authors

  • Jain, Lokesh; Sissung, Tristan M; Danesi, Romano; Kohn, Elise C; Dahut, Wi L; Kummar, Shivaani; Venzon, David; Liewehr, David; English, Bevin C; Baum, Caitlin E; Yarchoan, Robert; Giaccone, Giuseppe; Venitz, J├╝rgen; Price, Douglas K; Figg, William D

description

  • Hypertension (HT) and hand-foot skin reactions (HFSR) may be related to the activity of bevacizumab and sorafenib. We hypothesized that these toxicities would correspond to favorable outcome in these drugs, that HT and HFSR would coincide, and that VEGFR2 genotypic variation would be related to toxicity and clinical outcomes.

authors

publication date

  • 2010

start page

  • 95

volume

  • 29