Trivedi, Archit; Mehrotra, Aanchal; Baum, Caitlin E; Lewis, Brandon; Basuroy, Tupa; Blomquist, Thomas; Trumbly, Robert; Filipp, Fabian V; Setaluri, Vijayasaradhi; de la Serna, Ivana L
Pharmacologic inhibition of bromodomain and extra-terminal (BET) proteins is currently being explored as a new therapeutic approach in cancer. Some studies have also implicated BET proteins as regulators of cell identity and differentiation through their interactions with lineage-specific factors. However, the role of BET proteins has not yet been investigated in melanocyte differentiation. Melanocyte inducing transcription factor (MITF) is the master regulator of melanocyte differentiation, essential for pigmentation and melanocyte survival. In this study, we tested the hypothesis that BET proteins regulate melanocyte differentiation through interactions with MITF.