Mitochondrial dysfunction and consequences in calpain-3-deficient muscle Article (Faculty180)

cited authors

  • Jahnke, Van E; Peterson, Jennifer M; Van Der Meulen, Jack H; Boehler, Jessica; Uaesoontrachoon, Kitipong; Johnston, Helen K; Defour, Aurelia; Phadke, Aditi; Yu, Qing; Jaiswal, Jyoti K; Nagaraju, Kanneboyina


  • Nonsense or loss-of-function mutations in the non-lysosomal cysteine protease calpain-3 result in limb-girdle muscular dystrophy type 2A (LGMD2A). While calpain-3 is implicated in muscle cell differentiation, sarcomere formation, and muscle cytoskeletal remodeling, the physiological basis for LGMD2A has remained elusive.

publication date

  • 2020

published in

start page

  • 37


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