Chi, Andrew; Shirodkar, Samir P; Escudero, Di O; Ekwenna, Obi O O; Yates, Travis J; Ayyathurai, Rajinikanth; Garcia-Roig, Michael; Gahan, Jeffrey C; Manoharan, Murugesan; Bird, Vincent G; Lokeshwar, Vinata B
description
Molecular profiling of renal cell carcinomas (RCCs) may improve the distinction between oncocytoma and malignant RCC subtypes and aid in early detection of metastasis. The hyaluronic acid (HA) family includes HA synthases (HAS1, HAS2, HAS3), hyaluronidases (HYAL-1, HYAL-2, HYAL-3, HYAL-4, PH20, HYAL-P1), and HA receptors (CD44s, CD44v, RHAMM). HA family members promote tumor growth and metastasis. The authors evaluated the expression of HA family members in kidney specimens.
