Kramer, Mario W; Escudero, Di O; Lokeshwar, Soum D; Golshani, Roozbeh; Ekwenna, Obi O O; Acosta, Kristell; Merseburger, Axel S; Soloway, Mark; Lokeshwar, Vinata B
description
Cancer biomarkers are the backbone for the implementation of individualized approaches to bladder cancer (BCa). Hyaluronic acid (HA) and all 7 members of the HA family, that is, HA synthases (HA1, HA2, HA3), HYAL-1 hyaluronidase, and HA receptors (CD44s, CD44v, and RHAMM), function in tumor growth and progression. However, the diagnostic and prognostic potential of these 7 HA family members has not been compared simultaneously in any cancer. We evaluated the diagnostic and prognostic potential of HA family members in BCa.
