Inhibition of MMP2/MMP9 After Spinal Cord Trauma Reduces Apoptosis
Dang, Alexis B. C., MD*†; Tay, Bobby K.-B., MD*†; Kim, Hubert T., MD, PhD*†; Nauth, Aaron, BSc*†; Alfonso-Jaume, Maria Alexandra, PhD‡; Lovett, David H., MD‡Author Information
Spine: August 1, 2008 - Volume 33 - Issue 17 - p E576-E579
doi: 10.1097/BRS.0b013e31817ecc87
Abstract:
Disruption of the extracellular matrix after spinal cord injury is thought to be pathologic leading to apoptosis and myelin disruption. MMP2 is a potent MMP and is upregulated after spinal cord injury. Inhibition of MMP2/MMP9 significantly reduces apoptosis after SCI, leading to a possible therapeutic target.
