Haller, S T; Kennedy, David J; Shidyak, Amjad; Budny, George V; Malhotra, Deepak; Fedorova, Olga V; Shapiro, Joseph I; Bagrov, Alexei Y
description
Cardiotonic steroids (CTS) are implicated in pathophysiology of uremic cardiomyopathy. In the present study, we tested whether a monoclonal antibody (mAb) against the bufadienolide CTS, marinobufagenin (MBG), alleviates cardiac hypertrophy and fibrosis in partially nephrectomized (PNx) rats.
