Monoclonal antibody against marinobufagenin reverses cardiac fibrosis in rats with chronic renal failure Article (Faculty180)

cited authors

  • Haller, S T; Kennedy, David J; Shidyak, Amjad; Budny, George V; Malhotra, Deepak; Fedorova, Olga V; Shapiro, Joseph I; Bagrov, Alexei Y


  • Cardiotonic steroids (CTS) are implicated in pathophysiology of uremic cardiomyopathy. In the present study, we tested whether a monoclonal antibody (mAb) against the bufadienolide CTS, marinobufagenin (MBG), alleviates cardiac hypertrophy and fibrosis in partially nephrectomized (PNx) rats.

publication date

  • 2012

published in

start page

  • 690

end page

  • 6


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