Passive immunization against marinobufagenin attenuates renal fibrosis and improves renal function in experimental renal disease Article (Faculty180)

cited authors

  • Haller, S T; Drummond, Christopher A; Yan, Yanling; Liu, Jiang; Tian, Jiang; Malhotra, Deepak; Shapiro, Joseph I


  • We have shown that the cardiotonic steroid marinobufagenin (MBG) is elevated in clinical and experimental renal disease, and significantly contributes to the development of experimental uremic cardiomyopathy induced by removal of five-sixths of the kidney (5/6 nephrectomy; PNx) in the rat. We have demonstrated that both active and passive immunization against MBG with an anti-MBG monoclonal antibody (mAb 3E9) significantly attenuated cardiac fibrosis following PNx. In the present study we sought to determine whether the use of mAb 3E9 could improve renal function following PNx.

publication date

  • 2014

published in

start page

  • 603

end page

  • 9


  • 27