Arginase blockade lessens endothelial dysfunction after thrombosis Article (Faculty180)

cited authors

  • Lewis, Chandani; Zhu, Weifei; Pavkov, Mircea L; Kinney, Corttrell M; Dicorleto, Paul E; Kashyap, Vikram S


  • Acute arterial thrombosis causes endothelial dysfunction due to decreased nitric oxide bioactivity. Increased arginase activity may modulate intracellular L-arginine levels, the substrate for nitric oxide. The purpose of this study was to identify the role of arginase in endothelial dysfunction in cell culture and in the vasomotor response of arteries exposed to thrombus.


publication date

  • 2008

published in

start page

  • 441

end page

  • 6


  • 48