Brn3c null mutant mice show long-term, incomplete retention of some afferent inner ear innervation Article (Faculty180)

cited authors

  • Xiang, Mengqing; Maklad, Adel; Pirvola, Ulla; Fritzsch, Bernd


  • Ears of Brn3c null mutants develop immature hair cells, identifiable only by certain molecular markers, and undergo apoptosis in neonates. This partial development of hair cells could lead to enough neurotrophin expression to sustain sensory neurons through embryonic development. We have therefore investigated in these mutants the patterns of innervation and of expression of known neurotrophins.


publication date

  • 2003

published in

start page

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