Oxyamination of Unactivated Alkenes with Electron-Rich Amines and Acids via a Catalytic Triiodide Intermediate Article (Faculty180)

cited authors

  • Wu, Fan; Ariyarathna, Jeewani P; Alom, Nur-E; Kaur, Navdeep; Li, Wei


  • An aerobic catalytic oxidation process is described for the olefin oxyamination using acids and primary amines as the sources of O and N. Our mechanistic findings point to the formation of triiodide as a critical catalytic intermediate to account for the tolerance of electron-rich nucleophiles. This dual iodide and copper catalytic system is suitable for a formal [5+1] annulation process to access valuable lactam structures and highlighted by the synthesis of the pharmaceutical Zamifenacin.


publication date

  • 2020

published in

start page

  • 884

end page

  • 890


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