One-Pot Strategy for Thiazoline Synthesis from Alkenes and Thioamides Article (Faculty180)

cited authors

  • Alom, Nur-E; Wu, Fan; Li, Wei


  • A convenient synthesis of a privileged pharmaceutical motif, thiazoline is accomplished. This reaction utilizes simple and readily available alkene and thioamide substrates in an intermolecular fashion via a simple one-pot procedure. A wide range of functional groups is tolerated, and the thiazoline product has been further utilized for the synthesis of the corresponding β-aminothiol and thiazole from routine hydrolysis and oxidation protocols.


publication date

  • 2017

published in

start page

  • 930


  • 19