Enantioselective decarboxylative arylation of $alpha$-amino acids via the merger of photoredox and nickel catalysis Article (Faculty180)

cited authors

  • Zuo, Zhiwei; Cong, Huan; Li, Wei; Choi, Junwon; Fu, Gregory C; MacMillan, David WC


  • An asymmetric decarboxylative Csp3–Csp2 cross-coupling has been achieved via the synergistic merger of photoredox and nickel catalysis. This mild, operationally simple protocol transforms a wide variety of naturally abundant α-amino acids and readily available aryl halides into valuable chiral benzylic amines in high enantiomeric excess, thereby producing motifs found in pharmacologically active agents.


publication date

  • 2016

start page

  • 1832


  • 138