Comparative In Vitro Activities and Postantibiotic Effects of the Oxazolidinone Compounds Eperezolid (PNU-100592) and Linezolid (PNU-100766) versus Vancomycin against
Staphylococcus aureus
, Coagulase-Negative Staphylococci,
Enterococcus faecalis
, and
Enterococcus faecium
Article (Web of Science)
ABSTRACT
The activities of the oxazolidinone antibacterial agents eperezolid (PNU-100592) and linezolid (PNU-100766) were compared with that of vancomycin against clinical isolates of methicillin-susceptible and -resistant
Staphylococcus aureus
(
n
= 200), coagulase-negative staphylococci (
n
= 100), and vancomycin-susceptible and -resistant
Enterococcus faecalis
and
Enterococcus faecium
(
n
= 50). Eperezolid and linezolid demonstrated good in vitro inhibitory activity, regardless of methicillin susceptibility for staphylococci (MIC at which 90% of the isolates are inhibited [MIC
90
] range, 1 to 4 μg/ml) or vancomycin susceptibility for enterococci (MIC
90
range, 1 to 4 μg/ml). In time-kill studies, eperezolid and linezolid were bacteriostatic in action. A postantibiotic effect of 0.8 ± 0.5 h was demonstrated for both eperezolid and linezolid against
S. aureus
,
S. epidermidis
,
E. faecalis
, and
E. faecium.