The Connector Domain of Vesicular Stomatitis Virus Large Protein Interacts with the Viral Phosphoprotein Article (Web of Science)


  • This study represents the first functional assignment of the connector domain of a Mononegavirales L protein. Furthermore, this study localizes P polymerase cofactor activity to specific amino acids. The functional necessity of this interaction, combined with the uniqueness of L and P proteins to the order Mononegavirales , makes disruption of the P-connector site a potential target for developing antivirals against other negative-strand RNA viruses. Furthermore, the connector domain as an acceptor site for the P protein represents a new understanding of Mononegavirales L protein biology.


  • Gould, Joseph R.
  • Qiu, Shihong
  • Shang, Qiao
  • Ogino, Tomoaki
  • Prevelige, Peter E.
  • Petit, Chad M.
  • Green, Todd J.

publication date

  • 2020

published in


  • 94


  • 6