Design and Synthesis of 4-O-Podophyllotoxin Sulfamate Derivatives as Potential Cytotoxic Agents Article (Web of Science)

abstract

  • 4-O-Podophyllotoxin sulfamate derivatives were prepared using the natural lignan podophyllotoxin. The prepared compounds were afforded by reacting O-sulfonyl chloride podophyllotoxin with ammonia or aminoaryl/heteroaryl motif. Biological evaluation was performed in human breast cancer (MCF7), ovarian cancer (A2780), colon adenocarcinoma (HT29), and normal lung fibroblast (MRC5) cell lines. Compound 3 exhibited potent inhibitory activity and good selectivity margin. Compounds 2, 3, and 7 exerted apoptotic effect in MCF7 cells in a dose-dependent manner. The cytotoxicity of the verified compounds was inferior to that of podophyllotoxin.

authors

  • Bader, Ammar
  • Bkhaitan, Majdi M.
  • Abdalla, Ashraf N.
  • Abdallah, Qasem M. A.
  • Ali, Hamed I.
  • Sabbah, Dima A.
  • Albadawi, Ghadeer
  • Abushaikha, Ghassan M Talab

publication date

  • 2021

number of pages

  • 6

start page

  • 1

end page

  • 7

volume

  • 2021