Geographic Distribution of a Large Mobile Element That Transfers Ampicillin and Vancomycin Resistance between
Enterococcus faecium
Strains
Article (Web of Science)
ABSTRACT
In several clonally unrelated VanB-type vancomycin-resistant
Enterococcus faecium
strains, we demonstrated a common physical relationship between
pbp5
and Tn
5382
as well as common mutations within
pbp5
. The majority of these strains transferred vancomycin and ampicillin resistance to
E. faecium
in vitro, suggesting the dissemination of similar transferable
pbp5-vanB
-containing mobile elements throughout the United States.