Mannose 6-phosphate receptor homology (MRH) domain-containing lectins in the secretory pathway Article (Faculty180)

cited authors

  • Castonguay, Ali C; Olson, Linda J; Dahms, Nancy M


  • The mannose 6-phosphate receptor homology (MRH) domain-containing family of proteins, which include recycling receptors (mannose 6-phosphate receptors, MPRs), resident endoplasmic reticulum (ER) proteins (glucosidase II β-subunit, XTP3-B, OS-9), and a Golgi glycosyltransferase (GlcNAc-phosphotransferase γ-subunit), are characterized by the presence of one or more MRH domains. Many MRH domains act as lectins and bind specific phosphorylated (MPRs) or non-phosphorylated (glucosidase II β-subunit, XTP3-B and OS-9) high mannose-type N-glycans. The MPRs are the only proteins known to bind mannose 6-phosphate (Man-6-P) residues via their MRH domains.

publication date

  • 2011

published in

start page

  • 815

end page

  • 26


  • 1810