Yasmin, Mohamad; Hanrahan, Jennifer; Marshall, Steven; Lodise, Thomas P; Chen, Liang; Perez, Federico; Kreiswirth, Barry; Bonomo, Robert A
description
This report describes the treatment of carbapenemase (KPC)-3-producing multidrug-resistant with ceftazidime/avibactam (CAZ-AVI) in a patient who developed postneurosurgical meningitis and bacteremia. Therapeutic drug monitoring of cerebrospinal fluid and blood samples demonstrated CAZ-AVI concentration levels 20-fold greater than the minimum inhibitory concentration in the first 60 minutes postinfusion, providing evidence for the utility of CAZ-AVI in treating KPC- central nervous system infections.
