Applicant : The University of Toledo , Toledo , OH ( US )
(Inventors : Shahnawaz Imam , Toledo , OH ( US ) ; Maria Alfonso - Jaume , Toledo , OH ( US ) ; Juan Carlos Jaume , Toledo , OH ( US )
Publication Classification
( 51 ) Int . Ci . A01K 67/027 ( 2006.01 )
A61K 49/00 ( 2006.01 )
( 52 ) U.S. Ci . CPC A01K 67/0275 ( 2013.01 ) ; A61K 49/0008
( 2013.01 ) ; AOIK 2267/0362 ( 2013.01 ) ; AOIK
2227/105 ( 2013.01 ) ; AOIK 2217/05 ( 2013.01 )
( 57 ) ABSTRACT
A mouse model that develops type 1 diabetes spontaneously and used thereof are described . In some embodiments , the
mouse model expresses a combination of HLA - DQ8 and GAD65 in a C57BL / 6 - BTBR congenic background , where
the GAD65 is expressed under the rat insulin promoter . Specification includes a Sequence Listing .
( 73 ) Assignee : The University of Toledo , Toledo , OH ( US )
( 21 ) Appl . No .: 16 / 530,452
( 22 ) Filed : Aug. 2 , 2019
Pub . Date : Feb. 6 , 2020