Rasool, Mohammed I; Bairam, Ahsan F; Gohal, S A; El Daibani, Amal A A; Alherz, F A; Abunnaja, Maryam S; Alatwi, Eid S; Kurogi, Katsuhisa; Liu, Ming- C
description
Non-opioid and opioid analgesics, as over-the-counter or prescribed medications, are widely used for the management of a diverse array of pathophysiological conditions. Previous studies have demonstrated the involvement of human cytosolic sulfotransferase (SULT) SULT1A1 in the sulfation of acetaminophen, O-desmethylnaproxen (O-DMN), and tapentadol. The current study was designed to investigate the impact of single nucleotide polymorphisms (SNPs) of the human SULT1A1 gene on the sulfation of these analgesic compounds by SULT1A1 allozymes.
