Karthikeyan, Chandrabose; Amawi, Haneen; Ashby, Cha R; Khare, Vishwa M; Jones, Veronica; Hari Narayana Moorthy, N S; Trivedi, Piyush; Tiwari, Amit K
description
A novel series of 3-((2-chloroquinolin-3-yl)methylene)indolin-2-ones were synthesized, using the 'molecular hybridization approach' and evaluated for anticancer efficacy. Eleven 3-((2-chloroquinolin-3-yl)methylene)indolin-2-ones ( to ) were synthesized and evaluated for cytotoxic efficacy in cancer (ovarian, prostate and colon) and two non-cancerous cell lines. Among the 3-((2-chloroquinolin-3-yl)methylene)indolin-2-one derivatives, with a 6-Cl substitution in the 3-quinolinyl moiety, had selective and potent cytotoxic efficacy in the ovarian cancer cell line A2780. Further mechanistic investigations indicated that significantly inhibited the clonogenic survival of A2780 cancer cells, which was mediated by inducing apoptosis.
