Ghassan M Talab Abushaikha
Contact Info
Publications
selected publications
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Article (Faculty180)
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2026
Development of a Novel PI3K/CDK7 Potent Hybrid Inhibitor for Cancer Treatment
. Bioorg. Med. Chem. Lett.. -
2026
N-Benzyl-6-Chloro-4-Hydroxy-2-Quinolone-3-Carboxamides: Synthesis, Computational Studies, and Biological Investigation as Anticancer Agents
. Molecules (Basel, Switzerland). 31. -
2026Erratum to "Development of a novel PI3Kα/CDK7 potent hybrid inhibitor for Cancer treatment" [Bioorg. Med. Chem. Lett. 140 (2026) 130738]. Bioorganic & medicinal chemistry letters. 141:130748.
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2026Investigating the Anticancer Promise of Synthesized Methylated N-Substituted-4-Hydroxy-2-Quinolone-3-Carboxamides: Biological and Computational Characterization. Chemical biology & drug design. 107:e70324.
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2022Phenanthridine Sulfonamide Derivatives as Potential DPP-IV Inhibitors: Design, Synthesis and Biological Evaluation. Current computer-aided drug design. 18:9-25.
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2021Design and Synthesis of 4-O-Podophyllotoxin Sulfamate Derivatives as Potential Cytotoxic Agents. Evidence-based complementary and alternative medicine : eCAM. 2021:6672807.
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2021Evaluation of the anticancer activity and fatty acids composition of "Handal" ( L.) seed oil, a desert plant from south Jordan. Food science & nutrition. 9:282-289.
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2021New derivatives of sulfonylhydrazone as potential antitumor agents: Design, synthesis and cheminformatics evaluation. Acta pharmaceutica (Zagreb, Croatia). 71:545-565.
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2018
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2018
Structure-Based Design: Synthesis, X-ray Crystallography, and Biological Evaluation of N-Substituted-4-Hydroxy-2-Quinolone-3-Carboxamides as Potential Cytotoxic Agents
. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY. -
2018Benzoin Schiff Bases: Design, Synthesis, and Biological Evaluation as Potential Antitumor Agents. Medicinal chemistry (Shariqah (United Arab Emirates)). 14:695-708.
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2018Structure-Based Design: Synthesis, X-ray Crystallography, and Biological Evaluation of N-Substituted-4-Hydroxy-2-Quinolone-3-Carboxamides as Potential Cytotoxic Agents. Anti-cancer agents in medicinal chemistry. 18:263-276.
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2018Synthesis and in Vivo Lipid-Lowering Activity of Novel Imidazoles-5-carboxamide Derivatives in Triton-WR-1339-Induced Hyperlipidemic Wistar Rats. Chemical & pharmaceutical bulletin. 66:953-958.
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2018Synthesis of Novel Benzimidazole-2-carboxamide Derivatives and in Vivo Antihyperlipidemic Activity Evaluation. Chemical & pharmaceutical bulletin. 66:423-426.
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2018Synthesis, Structural Characterization and Docking Studies of Sulfamoyl- Phenyl Acid Esters as Dipeptidyl Peptidase-IV Inhibitors. Current computer-aided drug design. 14:142-151.
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2017
CETP Inhibitory Activity of Chlorobenzyl Benzamides: QPLD Docking, Pharmacophore Mapping and Synthesis
. LETTERS IN DRUG DESIGN & DISCOVERY. -
2017
Facile synthesis, characterization, and cytotoxicity study of new 3-(indol-2-yl)bicyclotetrazatridecahexaens
. CANADIAN JOURNAL OF CHEMISTRY. -
2017
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2017Molecular Docking and Pharmacophore Modeling Studies of Fluorinated Benzamides as Potential CETP Inhibitors. Medicinal chemistry (Shariqah (United Arab Emirates)). 13:239-253.
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2017N-(3-Benzoylphenyl)-1H-Indole-2-Carboxamide decreases triglyceride levels by downregulation of Apoc3 gene expression in acute hyperlipidemic rat model. Molecular and cellular biochemistry. 431:133-138.
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2017
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2017
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2016
Computer-aided design, synthesis, and biological evaluation of new indole-2-carboxamide derivatives as PI3Kα/EGFR inhibitors
. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. -
2016Computer-aided design, synthesis, and biological evaluation of new indole-2-carboxamide derivatives as PI3Kα/EGFR inhibitors. Bioorganic & medicinal chemistry letters. 26:2685-90.
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2015
Computational Docking Studies of Novel Heterocyclic Carboxamides as Potential PI3Kα Inhibitors
. LETTERS IN DRUG DESIGN & DISCOVERY. -
2015
Molecular modeling based approach, synthesis, and cytotoxic activity of novel benzoin derivatives targeting phosphoinostide 3-kinase (PI3Kα)
. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. -
2015
Synthesis and Preliminary Biological Evaluation of New Heterocyclic Carboxamide Models
. LETTERS IN DRUG DESIGN & DISCOVERY. -
2015Molecular modeling based approach, synthesis, and cytotoxic activity of novel benzoin derivatives targeting phosphoinostide 3-kinase (PI3Kα). Bioorganic & medicinal chemistry letters. 25:3120-4.
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2014
Synthesis and Pharmacological Evaluation of Novel Unsubstituted Indole-Anthraquinone Carboxamide Derivatives as Potent Antihyperlipidemic Agents
. ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES. -
2014Synthesis and pharmacological evaluation of novel unsubstituted indole-anthraquinone carboxamide derivatives as potent antihyperlipidemic agents. Zeitschrift fur Naturforschung. C, Journal of biosciences. 69:21-8.
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2013
The Pharmacological effects of novel 5-fluoro-N-(9,10-dihydro-9,10-dioxoanthracen-8-yl)-1H-indole-2-carboxamide derivatives on plasma lipid profile of Triton-WR-1339-induced Wistar rats
. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY. -
2013Design, Synthesis and Biological Evaluation of N4-Sulfonamido-Succinamic, Phthalamic, Acrylic and Benzoyl Acetic Acid Derivatives as Potential DPP IV Inhibitors. The open medicinal chemistry journal. 7:39-48.
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2013The pharmacological effects of novel 5-fluoro-N-(9,10-dihydro-9,10-dioxoanthracen-8-yl)-1H-indole-2-carboxamide derivatives on plasma lipid profile of Triton-WR-1339-induced Wistar rats. Journal of enzyme inhibition and medicinal chemistry. 28:863-9.
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2012
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2012In vivo antihyperlipidemic activity of a new series of N-(benzoylphenyl) and N-(acetylphenyl)-1-benzofuran-2-carboxamides in rats. Archiv der Pharmazie. 345:401-6.
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2011Antihyperlipidemic properties of novel N-(benzoylphenyl)-5-substituted-1H-indole-2-carboxamides in Triton WR-1339-induced hyperlipidemic rats. Molecules (Basel, Switzerland). 16:8292-304.
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2011
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2011Some sulfonamide drugs inhibit ATPase activity of heat shock protein 90: investigation by docking simulation and experimental validation. Journal of enzyme inhibition and medicinal chemistry. 26:603-9.
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2011Synthesis of benzothiophene carboxamide derivatives and their pharmacological evaluation as potent antihypertriglyceridemic agents in rats. Zeitschrift fur Naturforschung. C, Journal of biosciences. 66:93-103.
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2010
Discovery of new cholesteryl ester transfer protein inhibitors via ligand-based pharmacophore modeling and QSAR analysis followed by synthetic exploration
. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. -
2010
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2010Design, synthesis, and biological evaluation of benzylamino-methanone based cholesteryl ester transfer protein inhibitors. Molecules (Basel, Switzerland). 15:5721-33.
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2010Discovery of new cholesteryl ester transfer protein inhibitors via ligand-based pharmacophore modeling and QSAR analysis followed by synthetic exploration. European journal of medicinal chemistry. 45:1598-617.
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2010Pharmacophore and QSAR modeling of estrogen receptor beta ligands and subsequent validation and in silico search for new hits. Journal of molecular graphics & modelling. 28:383-400.
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2010Synthesis and anti-hyperlipidemic evaluation of N‑(benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide derivatives in Triton WR-1339-induced hyperlipidemic rats. Molecules (Basel, Switzerland). 15:5840-9.
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2010Synthesis and pharmacological evaluation of novel substituted and unsubstituted N-(benzoylphenyl)-1H-indole-2-carboxamides as potent antihypertriglyceridemic agents. Zeitschrift fur Naturforschung. C, Journal of biosciences. 65:309-16.
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2009
Homology modeling of MCH1 receptor and validation by docking/scoring and protein-aligned CoMFA
. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. -
2009
Novel Derivatives of 1,3-Dimethyl-5-methylenebarbituric Acid
. LETTERS IN ORGANIC CHEMISTRY. -
2009
Pharmacological Evaluation of Novel Indole-2-carboxamides As Potent Lipid-Lowering Agents in Triton-WR-1339-Induced Hyperlipidemic Rats
. ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES. -
2009Homology modeling of MCH1 receptor and validation by docking/scoring and protein-aligned CoMFA. European journal of medicinal chemistry. 44:2583-96.
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2009Pharmacological evaluation of novel indole-2-carboxamides as potent lipid-lowering agents in Triton-WR-1339-induced hyperlipidemic rats. Zeitschrift fur Naturforschung. C, Journal of biosciences. 64:619-25.
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2007Study of the effects on DNA of two novel nucleoside derivatives synthesized as potential anti-HIV agents. Drug and chemical toxicology. 30:41-53.
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2002A new class of acyclic nucleoside phosphonates: synthesis and biological activity of 9-[[(phosphonomethyl)aziridin-1-yl]methyl]guanine (PMAMG) and analogues. Nucleosides, nucleotides & nucleic acids. 21:619-35.
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2000A new acyclic heterodinucleotide active against human immunodeficiency virus and herpes simplex virus. Antiviral research. 47:149-58.
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1999Effect of acyclic nucleoside phosphonates on the HIV-1 integrase in vitro. Nucleosides & nucleotides. 18:849-51.
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1999Synthesis and biological application of a new heterodinucleotide with both anti-HSV and anti-HIV activity. Nucleosides & nucleotides. 18:989-90.
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1998Potent and selective inhibitors of human immunodeficiency virus protease structurally related to L-694,746. Antiviral chemistry & chemotherapy. 9:303-9.
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1997
Synthesis and IMP dehydrogenase (type I and type II) inhibitory activity of isosteric NAD analogs derived from thiophenfurin and furanfurin
. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS. -
1997
Synthesis and cytotoxic activity of selenophenfurin, a new inhibitor of IMP dehydrogenase
. NUCLEOSIDES & NUCLEOTIDES. -
1997
Synthesis of unsaturated analogues of 9-[2-(phosphonomethoxy)propyl]guanine as antiviral agents
. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS. -
1997
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1995
ACYCLIC NUCLEOTIDES RELATED TO CLITOCINE - SYNTHESIS AND ANTI-HIV ACTIVITY
. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS. -
1995Synthesis and antiviral activity of 8-aza analogs of chiral [2-(phosphonomethoxy) propyl]guanines. Journal of medicinal chemistry. 38:4007-13.
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1994Synthesis and evaluation of the anti-HIV activity of aza and deaza analogues of isoddA and their phosphates as prodrugs. Journal of medicinal chemistry. 37:3534-41.
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Article (Web of Science)
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2021Design and Synthesis of 4-O-Podophyllotoxin Sulfamate Derivatives as Potential Cytotoxic Agents. Evidence-Based Complementary and Alternative Medicine. 2021:1-7.Full Text via DOI: 10.1155/2021/6672807
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2020Synthesis and Antiproliferative Activity of 4β‐ O ‐Substituted, 4β‐ N ‐Substituted Deoxypodophyllotoxin Derivatives, and 4β‐ O H‐ 4’‐ O ‐Substituted Podophyllotoxin. CHEMISTRYSELECT. 5:14924-14929.Full Text via DOI: 10.1002/slct.202003810
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Proceedings (Faculty180)
Contact
full name
- Ghassan M Talab Abushaikha